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Assoc. Prof. Dr. Kanakeswary

Associate Professor – Faculty of Medicine

Qualifications:

  • PhD (Physiology)
    University of Western Australia (Perth) – 2016
  • MSc Medical Science (by research)
    International Medical University (Kuala Lumpur) – 2009
  • BSc Biomedical Science (Medical Laboratory Technologist) 
    University Putra Malaysia – 1998
    (CGPA: 3.5 out of 4.0)

Teaching Experience

  • Senior Lecturer 
    Physiology Department, School of medicine
    Perdana University –Royal College of surgeons in Ireland (Kuala Lumpur)
    2017- 2021
  • Lecturer III 
    Life Science Department, School of Pharmacy International Medical University (Kuala Lumpur)
    2015-2017
  • Tutor/Lab demonstrator
    School of Anatomy, Physiology and Human Biology University of Western Australia (Perth)
    2012-2014
  • Lecturer II
    Life Science Department, School of Pharmacy International Medical University (Kuala Lumpur)
    2009-2011
  • Laboratory Scientist 
    Research Laboratory International Medical University (Kuala Lumpur)
    2004-2008
  • Medical Laboratory Technologist
     Multidisciplinary Laboratory International Medical University (Kuala Lumpur)
    1998-2004

Research interests

Dr Kana undertakes preclinical research primarily in muscle physiology and inflammation, natural products and exercise physiology. She is also involved in public health research on child obesity, body image and child abuse. Other research interest include prescribing readiness of medical graduates and medical education.

Projects:

  1. Detection of Bt18 parasporal protein binding to Human Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) using immunoblot and immunoflurescence microscopy.
    B. Med.Sc - March 2009
  2. Examination of age-related difference in the neuronal density and GFAP expression in hippocampus and cerebellum produced by dermal exposure to chlorpyrifos in Swiss albino mice.
    BPharm-July 2009
  3. A preliminary study to examine the difference in neurosphere differentiation in embryonic neural stem cell culture of Sprague-Dawley rats with different growth factors.
    B.MedSc-Nov 2009
  4. A comparative study to examine the differential neurotoxic effect of ethanol on cerebellar and cortical neurospheres isolated from mouse foetus.
    Bpharm – July 2010
  5. A study of the neurotoxic effects of intracisternal glutamate receptor agonists on the neurons and perikarya of forebrain and spinal cord in Sprague-Dawley rats
    B.MedSc- Nov 2010
  6. Anti-Inflammatory Properties of New Chemical Entities (NCE) on Lipopolysaccharide Induced Inflammation in Skeletal Muscle Cells. Bpharm - 2016
  7. Assessment of health-related risk behaviors among adults using behavioral risk factor surveillance system (BRFSS) survey. PU-RCSI Student selected projects 2018 (8 students)
  8. Mother’s perception of their children’s weight status and child’s perception of their own weight status and its correlation with weight -related parenting and child practices in semi-urban areas in Selangor. PU-RCSI Student selected projects 2019 (8 students)
  9. Children’s Body Image Scale (CBIS) for the assessment of body weight status among children in Selangor, Malaysia. PU-RCSI Student selected projects 2020 (2 students)
  10. Impact of multi-type childhood abuse on psychological development and the coping strategies among university students. PU-RCSI Student selected projects 2020 (2 students)

Summer Research projects:

  1. Evaluation of House Officers’ perceptions on prescribing skills and competencies in Malaysia. 2020
  2. Validity and reliability of Children’s Body Image Scale (CBIS) for the assessment of accurate perception of body weight status and body image among children in Malaysia. 2019
  3. Evaluation of Medical students’ views on their prescribing skills and competencies in Malaysia. 2018

Student Selected projects 2021 for MBBS degree students:

  1. Comparison of International Colon Cancer Rates Using the CI5 Database (2 students).
  2. Self-perception of weight, body image and eating behaviors among urban children in Selangor (2 students).
  3. House officer’s perception on prescribing readiness in Malaysia (2 students).
  4. Association of physical inactivity and metabolic syndrome with breast cancer in postmenopausal women: A systematic review (1 student).
  5. Impact of exercise regimens on social cognition among autistic children: A systematic review (1 student).
  6. Child Abuse and Neglect/ Maltreatment and Coping Strategies and the impact towards mental health among University Students in Southern Klang Valley (2 student).
  7. In silico molecular docking analysis of Houttuynia cordata against SARS-CoV-2 protease and helicase (2 students).

    A total of 20 students supervised from year 2018-2020

PhD (Public Health) supervision

  1. Formulation of a Cognitive Enhancement Exercise schedule for Improvement of Autism Spectrum Disorder (ASD) Children Cognition And Parents Quality Of Life In Malaysia (Co-supervisor) March 2021

  1. Nurin Sarah Noor Azaf, Kyshanty Vizabaskaran, Kanakeswary Karisnan, Anne Jamaludin. Impact of Multi-Type Childhood Abuse on Psychological Development and the Coping Strategies among Perdana University Students. MJMHS.2021 Aug:17(5) (in press)
  2. Shuwaathi Thamilmanni, Calvin Preetivan Noris, Amuthaganesh Mathialagan, Kanakeswary Karisnan. Role of physical activity and metabolic syndrome in determining the risk of postmenopausal breast cancer: A systematic review. Int J Community Med Public Health. 2021;8(7). DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20212619
  3. B. Karikalan, A. G. Mathialagan, T. H. Sasongko, K. Karisnan, K. Kademane, Nazmul MHM (2021). Disease. Monitoring Parameters for Autoimmune Diseases. Asian Pacific Journal of Health Sciences, 8(1); 24-31. https://www.apjhs.com/index.php/apjhs/article/view/1153
  4. Thuraiveloo, S., Pillai, S., Karunakaran, L.G., Mui, S.S., Maxwell, S., Mathialagan, A.G., Karisnan, K. The Role of Prescribing Safety Assessment on Prescribing Readiness of Medical Students in Malaysia. South-East Asian Journal of Medical Education. 2020; 14(1), pp.40–45. DOI: http://doi.org/10.4038/seajme.v14i1.233
  5. Tan ZQ, Leow HY, Lee DCW, Karisnan K, Song AAL, Mai CW, Yap WS, Lim SHE, Lai KS. Co-Culture Systems for the Production of Secondary Metabolites: Current and Future Prospects. The Open biotechnology journal. 2019;13: 18-26. doi:10.2174/1874070701913010018
  6. Karisnan K, Mahzabin T, Bakker AJ, Song Y, Noble PB, Pillow JJ, Pinniger GJ. Gestational age at time of in utero lipopolysaccharide exposure influences the severity of inflammation-induced diaphragm weakness in lambs. Am J Physiol Regul Integr Comp Physiol. 2018 https://doi.org/10.1152/ajpregu.00150.2017
  7. Mahzabin T, Pillow JJ, Pinniger GJ, Bakker AJ, Noble PB, White RB, Karisnan K, Song Y. Influence of antenatal glucocorticoid on preterm lamb diaphragm. Pediatr Res. 2017;82(3):509-517.
  8. Karisnan K, Bakker AJ, Song Y, Noble PB, Pillow JJ, Pinniger GJ. Interleukin-1 receptor antagonist protects against lipopolysaccharide induced diaphragm weakness in preterm lambs. PLoS One. 2015;10(4):e0124390.
  9. Karisnan K, Bakker AJ, Song Y, Noble PB, Pillow JJ, Pinniger GJ. Gestational age at initial exposure to in utero inflammation influences severity of diaphragm dysfunction in preterm lambs. Respirology. 2015 Nov;20(8):1255-62).
  10. Song Y, Karisnan K, Noble PB, Berry CA, Lavin T, Moss TJ, Bakker AJ, Pinniger GJ, Pillow JJ. In utero LPS exposure impairs preterm diaphragm contractility. Am J Respir Cell Mol Biol. 2013;49(5):866-74.
  11. Krishnan K, Mitra NK, Yee LS, Yang HM. A comparison of Neurotoxicity in Cerebellum Produced by Dermal Application of Chlorpyrifos in young and Adult Mice. Journal of Neural Transmission. 2012 Mar;119(3):345-52.
  12. Krishnan K, Ker JE, SM Mohammed, VD Nadarajah. Identification of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a binding protein for a 68-kDa Bacillus thuringiensis parasporal protein cytotoxic against leukaemic cells. Journal of Biomedical Science 2010, 17:86.
  13. VD Nadarajah, D Ting, KK Chan, SM Mohamed, K Kanakeswary and HL Lee. Selective cytotoxic activity against leukaemic cell lines from mosquitocidal Bacillus thuringiensis parasporal inclusions. Southeast Asian Journal of Tropical Medicine and Public Health. 2008: 39 (2): 235-245.
  14. VD Nadarajah, SH Chai, SM Mohammed, KK Chan, K Kanakeswary. Malaysian mosquitocidal soil bacterium (Bacillus thuringiensis) strains with selective hemolytic and lectin activity against human and rat erythrocytes. Southeast Asian Journal of Tropical Medicine and Public Health; 2006: 37:67-77.

  • Best Poster, PU Research Day 2020 (and 3rd place)
  • MMA Research Grant 2019: Evaluation of house officers’ perception on prescribing skills and competencies in Malaysia
  • Best Poster, PU Research Day 2019
  • Kuala Lumpur International Neonatology Conference (KLINC) 2015 Best Investigator Award
  • University of Western Australia Scholarships for International Research (SIRF and UIS) 2011-2015
  • PSANZ Early Career award
  • AuPS Travel award
  • BMedSc Research grants 2009 & 2010
  • International Medical University MSc Degree sponsorship
  • IMU Achievement award (Development of new programme: Masters of Science in Molecular Medicine)
  • International Medical University 10 years’ service award
  • BSc (Biomedical Science) Deans list award for semester 5, 6, 7 and 8

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