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 Prof. Dr. Chan Chee Kai

Professor – Faculty of Medicine

Qualifications:

  • Ph.D (Australia National University)
  • B.Sc., M.Ed. (National University Singapore),

Teaching & Research Experience

  • 2020-2022 Assistant Professor, College of Science and Technology, Wenzhou-Kean University, Wenzhou, China
  • 2015-2020 Assistant Professor, Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nursultan, Kazakhstan
  • 2003-2014 Lecturer, Department of Genetics, La Trobe University, Melbourne, Victoria.
  • 2002-2003 Assistant Professor, National Institute of Education, Nanyang Technological University, Singapore
  • 2000-2001 Post-doctoral Fellow, Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland USA. A*STAR International Fellow (Singapore)

Research Interests

  • Big Data analysis, precision medicine and nutrigenomics for metabolic syndrome, diabetes, TB and neurological diseases.  
  • HPV and cervical cancer: understanding host susceptibility, HPV epidemiology and diagnostics
  • Enhancing gene therapy, gene and drug delivery

Teaching Interests

  • Medical Genetics
  • Biochemistry
  • Nutrigenomics

  • University Research Ethics Board (Nazarbayev University)

     

  • Recombinant DNA Supervisory Committee (La Trobe University)

  • University Senate (Nazarbayev Unievrsity)

  1. SW Choo, JL Chong, P Gaubert, S Pauklin, S Deng et al (2022) A collective statement in support of saving pangolins. Science of the Total Environment 824, 153666
  2. A Akhatova, CK Chan, A Azizan, G Aimagambetova (2022) The Efficacy of Therapeutic DNA Vaccines Expressing the Human Papillomavirus E6 and E7 Oncoproteins for Treatment of Cervical Cancer: Systematic Review. Vaccines 10 (1), 53, 2022. https://doi.org/10.3390/vaccines10010053
  3. T Issa, A Babi, A Issanov, A Akilzhanova, K Nurgaliyeva, Z Abugalieva, A Azizan, SA Khan, C K Chan, RAlibekova, G Aimagambetova (2021). Knowledge and awareness of human papillomavirus infection and human papillomavirus vaccine among Kazakhstani women attending gynecological clinics. PloS one 16 (12), e0261203 https://doi.org/10.1371/journal.pone.0261203
  4. Z Liu, G Tian, J Zhu, W Chen, W Dou, C Lee, C Chan, O Dib (2021) Machine Learning Approaches to Investigate the Relationship between Genetic Factors and Autism Spectrum Disorder. 4th International Conference on Machine Learning and Machine Intelligence 164-171. https://doi.org/10.1145/3490725.3490750
  5. W Dou, Y Liu, Z Liu, D Yerezhepov, U Kozhamkulov, A Akilzhanova, O Dib, C Chan (2021). An AutoML Approach for Predicting Risk of Progression to Active Tuberculosis based on Its Association with Host Genetic Variations. ICBBS 2021, October 29–31, 2021, Xiamen, China. https://doi.org/10.1145/3498731.3498743
  6. Aimagambetova G, Babi A, Issanov A, Akhanova S, Udalova N, Koktova S, Balykov A, Sattarkyzy Z, Abakasheva Z, Azizan A, Chan CK, Issa T (2021). The Distribution and Prevalence of High-Risk HPV Genotypes Other than HPV-16 and HPV-18 among Women Attending Gynecologists’ Offices in Kazakhstan. Biology 10 (8), 794. https://doi.org/10.3390/biology10080794.
  7. A Babi, T Issa, A Issanov, A Akilzhanova, K Nurgaliyeva, Z Abugalieva, T Ukybassova, Z Daribay, S Khan, C K Chan, A Azizan, G Aimagambetova (2021). Prevalence of high-risk human papillomavirus infection among Kazakhstani women attending gynecological outpatient clinics. International Journal of Infectious Diseases. https://doi.org/10.1016/j.ijid.2021.06.006.
  8. Zhetkenev, S., Khassan, A., Khamzina, A., Issanov A, Crape B., Akilzhanova A., Yerezhepov D., Kozhamkulov U. & Chan CK. (2021) Association of rs12722 COL5A1 with pulmonary tuberculosis: a preliminary case-control study in a Kazakhstani population. Mol Biol Rep. 48 (1) 691-699 https://doi.org/10.1007/s11033-020-06121-y
  9. Issa T, Babi A, Azizan A, Alikhanova R, Khan S, Issanov A, Chan CK, Aimagambetova G (2021) Factors associated with cervical cancer screening behaviour of women attending gynaecological clinics in Kazakhstan: A cross-sectional study. Women’s Health. 2021. doi:10.1177/17455065211004135
  10. Mukhtarova K, Kanderzhanova A, Issanov A, Chan CK. (2021) Genetic Variations Influencing Glucose Homeostasis and Insulin Secretion and their Associations with Autism Spectrum Disorder in Electron J Gen Med. 2021;18(2):em274. https://doi.org/10.29333/ejgm/9677
  11. Razbekova M, Alpamys I, Chan MY, Chan R, Yerezhepov D, Kozhamkulov U, Akilzhanova A, Chan CK (2021). Genetic factors associated with cardiovascular and obesity risks in a Kazakhstani population. BMJ Nutrition, Prevention and Health. 2021. 0. doi:10.1136/bmjnph-2020-000139
  12. Sofiya An, Akbota Kanderzhanova, Assel Akhmetova, Faye Foster, Chee Kai Chan (2020). “Chasing hope”: Parents’ perspectives on complementary and alternative interventions for children with autism in Kazakhstan. 24(7) 1817–1828. https://doi.org/10.1177/1362361320923494
  13. Sadykov, M., Azizan, A., Kozhamkulov, U. Akilzhanova, A. Yerezhepov D., Salfinger M& Chee Kai Chan (2020). Association of genetic variations in the vitamin D pathway with susceptibility to tuberculosis in Kazakhstan. Mol Biol Rep (2020). https://doi.org/10.1007/s11033-020-05255-3
  14. Cervical Cancer Screening and Prevention in Kazakhstan and Central Asia. Aimagambetova G, Chee Kai Chan, Ukybassova T, Imankulova B, Balykov A, Kongrtay K, Azizan A. (2020) J Med Screen. https://doi.org/10.1177/0969141320902482
  15. Chee Kai Chan, Gulzhanat Aimagambetova, Talshyn Ukybassova, Kuralay Kongrtay, Azliyati Azizan (2019). Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening and Vaccination- Review of Current Perspectives Journal of Oncology Volume 2019 Article ID 3257939, https://doi.org/10.1155/2019/3257939
  16. Sofiya An, Chee Kai Chan, Botagoz Kaukenova (2018). Families in transition: Parental perspectives of support and services for children with autism in Kazakhstan. International Journal of Disability, Development and Education. IF:0.576
  17. Daniel Hernández-Torrano, Syed Ali, Chee-Kai Chan. (2017). 1st year Medical students’ learning style preference and their correlation with performance in different subjects within the medical course. BMC Medical Education. 17(1) 131.IF:1.93
  18. Chee Kai Chan, Paul Beaver, Ayana Arystan, Kathryn Goozee, Ralph Martins. 2015. Application of Nutrigenomics for personalized intervention of Alzheimer’s disease and metabolic syndrome. The Herald of the Medical Center of President’s affairs administration of the republic of Kazakhstan 2015; 1(58): 58-60.
  19. C McDermott, S Diepstraten, J Vadolas, B McColl, CK Chan, A Hart. 2015. Reactivation of gamma- globin using CRISPR-CAS9 as a potential gene therapy for beta-thalassemia. Journal of Gene Medicine 17 (8-9), 214-214
  20. S Diepstraten, J Vadolas, B McColl, CK Chan, A Hart 2015. A Novel system for analysis and manipulation of Human Globin gene switching in vitro. Journal of Gene Medicine 17 (8-9), 206-206
  21. Stephen R Doyle, Ph.D.; Naga R.P. Kasinadhuni; Chee Kai Chan; Warwick N Grant (2013) Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signals. PLoS ONE 8(6). doi:10.1371/journal.pone.0067938.
  22. Duy Huynh; Dilara Akcora; Jordane Malaterre; Chee-Kai Chan; Xu-Ming Dai; Ivan Bertoncello; E. Richard Stanley; Robert George Ramsay (2013) CSF1 Receptor-Dependent colon development, homeostasis and inflammatory stress response. PLoS ONE 8 (2) e56951.doi:10.1371/journal.pone.0056951
  23. Stephen R Doyle, Chee Kai Chan and Warwick Grant (2011) Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism. BMC Biotechnology, 11:83doi:10.1186/1472-6750-11- 83
  24. Chee Kai Chan, Adam Hart, Anna Lister, Stephen Doyle (2011). Learning styles of 3rd year Genetics Students and their Affection and Perception of effectiveness of a range of Instructional Modes. Proceedings of the Australian Conference on Science and mathematics Education.
  25. Michal Ugarenko, Chee-Kai Chan, Abraham Nudelman, Ada Rephaeli, Suzanne M Cutts, Don R Phillips (2009). Development of pluronic micelle-encapsulated doxorubicin and formaldehyde-releasing prodrugs for localized anticancer chemotherapy. Oncology Research. 17(7): 283-99
  26. Duy Huynh, Xu-Ming Dai, Sayan Nandi, Sally Lightowler, Melanie Trivett, Chee-Kai Chan, Ivan Bertoncello, Robert G Ramsay, E Richard Stanley. (2009) Colony stimulating factor-1 dependence of paneth cell development in the mouse small intestine. 137(1): 136-44, 144.
  27. Stephen R Doyle, Chee Kai Chan (2008). Mitochondrial gene therapy: an evaluation of strategies for the treatment of mitochondrial DNA disorders. Human Gene Therapy. Dec;19(12): 1335-48
  28. Stephen R Doyle, Chee Kai Chan (2007). Differential intracellular distribution of DNA complexed with polyethyleneimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells. Genetic Vaccines and Therapy. 5: 11
  29. Duy D. Huynh, E. Vincan, T. Mantamadiotis, D. Purcell, CK Chan R. Ramsay (2007) Oncogenic properties of HIV-Tat in colorectal cancer cells. Current HIV Research, 5(4): 403-9.
  30. Tania Blanksby & Chee Kai Chan (2006) Feedback assessment of Science report writing for first year Genetics students . UNISERVE Symposium, Assessment in Science Teaching and Learning.
  31. Loveland, A.N. Chee-Kai Chan, Edward J. Brignole and Wade Gibson (2005) Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity. J Virol 79 (20), 12961-12968
  32. Duy K. Pham and Chee Kai Chan. (2005) Impact of Polymeric Surfaces on Oligonucleotides Immobilization for Lab-On-A-Chip Applications, Trends in DNA Research (Nova Science Publishers) Edit: Corey Woods
  33. Chan, C.K. et al. (2002) Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions. J Virol 76 (17), 8667-8674
  34. Chan, C.K. and Jans, D.A. (2002) Using nuclear targeting signals to enhance non-viral gene Immunol Cell Biol 80 (2), 119-130
  35. Chan, C.K. and Jans, D.A. (2001) Enhancement of MSH receptor- and GAL4-mediated gene transfer by switching the nuclear import pathway. Gene Ther 8 (2), 166-171
  36. Chan, C.K. et al. (2000) Supramolecular structure and nuclear targeting efficiency determine the enhancement of transfection by modified polylysines. Gene Ther 7 (19), 1690-1697
  37. Hubner, S. et al. (1999) Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta. J Biol Chem 274 (32), 22610-22617
  38. Chan, C.K. and Jans, D.A. (1999) Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence. Hum Gene Ther 10 (10), 1695-1702
  39. Chan, C.K. and Jans, D.A. (1999) Synergy of importin alpha recognition and DNA binding by the yeast transcriptional activator GAL4. FEBS Lett 462 (1-2), 221-224
  40. Jans, DA et al. (1998) Signals mediating nuclear targeting and their regulation: application in drug delivery. Med Res Rev 18 (4), 189-223
  41. Chan, C.K. et al. (1998) Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for nonviral DNA delivery. Gene Ther 5 (9), 1204-1212
  42. Goh NK, Chan CK & Chia LS. (1995). A comparison of the differences of two teaching strategies in the modification of students’ misconceptions in science. ACCESS , 13(2); 161-171.
  43. Goh NK, Chan CK & Chia LS. (1995). Gender differences, misconceptions and instruction in Singapore J. Edu. 15: 33-41.

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